Sevoflurane Alleviates Reperfusion Arrhythmia by Ameliorating TDR and MAPD90 in Isolated Rat Hearts after Ischemia-Reperfusion
نویسندگان
چکیده
منابع مشابه
Myocardium functional recovery protection by omeprazole after ischemia-reperfusion in isolated rat hearts.
OBJECTIVE To evaluate the myocardium contractility alterations of isolated hearts of rats, submitted to ischemia and reperfusion with and without administration of the omeprazole. METHODS Twelve Wistar breed rats with 270 g mean body weight was studied. After anesthesia by intraperitoneal injection of ketamine 10mg and xylazine 2mg, their hearts were removed and perfused with Krebs-Henseleit ...
متن کاملMyocardial Oxidative Metabolism Early After Reperfusion in Isolated Rat Hearts
The present investigation studied the effect of increasing severities of ischemic injury on recovery of oxidative metabolism after reperfusion in isolated rat hearts perfused retrogradely with erythrocyte-containing medium. Hearts subjected to 60 minutes of low-flow ischemia (5% of control perfusion) exhibited delayed but sustained recovery of left ventricular pressure development during reperf...
متن کاملSevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts.
UNLABELLED Reactive oxygen species (ROS) are largely responsible for cardiac injury consequent to ischemia and reperfusion, but, paradoxically, there is evidence suggesting that anesthetics induce preconditioning (APC) by generating ROS. We hypothesized that sevoflurane generates the ROS superoxide (O(2)(.-)), that APC attenuates O(2)(.-) formation during ischemia, and that this attenuation is ...
متن کاملDetermination of oxidative stress and cardiac dysfunction after ischemia/reperfusion injury in isolated rat hearts.
BACKGROUND Oxidative stress due to reactive oxygen species (ROS) is thought to play a considerable role in ischemia/reperfusion (I/R) injury that impairs cardiac function. The present study examined oxidative damage in I/R injury and investigated the correlation between oxidative stress and impaired cardiac function after I/R injury of the isolated rat heart. METHODS Hearts isolated from male...
متن کاملPlatelets protect against myocardial dysfunction and injury induced by ischemia and reperfusion in isolated rat hearts.
Platelets are a source of vasoactive mediators that regulate vascular tone. Platelets also play a role in intravascular thrombus formation and dynamic coronary constriction that result in myocardial ischemia. However, effects of platelets on myocardial function after ischemia and reperfusion are unknown. In this study, we examined the effects of platelets on myocardial dysfunction caused by isc...
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ژورنال
عنوان ژورنال: Anesthesiology Research and Practice
سال: 2019
ISSN: 1687-6962,1687-6970
DOI: 10.1155/2019/7910930